Recommendations for the assessment and optimization of adherence to disease-modifying drugs in chronic inflammatory rheumatic diseases: A process based on literature reviews and expert consensus
Identifieur interne : 000247 ( Main/Exploration ); précédent : 000246; suivant : 000248Recommendations for the assessment and optimization of adherence to disease-modifying drugs in chronic inflammatory rheumatic diseases: A process based on literature reviews and expert consensus
Auteurs : Laure Gossec [France] ; Anna Molt [France] ; Xavier Romand [France] ; Déborah Puyraimond-Zemmour [France] ; Matthieu Lavielle [France] ; Catherine Beauvais [France] ; Eric Senbel ; René-Marc Flipo [France] ; Sophie Pouplin [France] ; Christophe Richez [France] ; Alain Saraux [France] ; Maryse Mezieres [France] ; Loriane Gutermann [France] ; Philippe Gaudin [France] ; Daniel Wendling [France] ; Maxime Dougados [France]Source :
- Joint Bone Spine [ 1297-319X ] ; 2019-01.
English descriptors
Abstract
BACKGROUND:Adherence to treatment is a key issue in chronic inflammatory rheumatic diseases (CIRDs).OBJECTIVE:To develop recommendations to facilitate in daily practice, the management of non-adherence to disease-modifying drugs in patients with rheumatoid arthritis, spondyloarthritis, psoriatic arthritis, connective tissue diseases or other CIRDs.METHODS:The process comprised (a) systematic literature reviews of methods (including questionnaires) to measure non-adherence, risk factors for non-adherence and efficacy of targeted interventions; (b) development of recommendations through consensus of 104 rheumatologist and nurse experts; (c) assessment of agreement and ease of applicability (1-5 where 5 is highest) by the 104 experts.RESULTS:(a) Overall, 274 publications were analysed. (b) The consensus process led to 5 overarching principles and 10 recommendations regarding adherence. Key points include that adherence should be assessed at each outpatient visit, at least using an open question; questionnaires and hydroxychloroquine blood level assessments may also be useful. Risk factors associated to non-adherence were listed. Patient information and education, and patient/physician shared decision, are key to optimize adherence. Other techniques such as formalized education sessions, motivational interviewing and cognitive behavioral therapy may be useful. All health professionals can get involved and e-health may be a support. (c) The agreement with the recommendations was high (range of means, 3.9-4.5) but ease of applicability was lower (2.7-4.4).CONCLUSIONS:Using an evidence-based approach followed by expert consensus, this initiative should improve the assessment and optimization of adherence in chronic inflammatory rheumatic disorders.
Url:
DOI: 10.1016/j.jbspin.2018.08.006
Affiliations:
- France
- Auvergne-Rhône-Alpes, Rhône-Alpes
- Grenoble
- Université Grenoble-Alpes, Université Joseph Fourier, Université de Grenoble
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Le document en format XML
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59037 Lille Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chru-lille.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Pouplin, Sophie" sort="Pouplin, Sophie" uniqKey="Pouplin S" first="Sophie" last="Pouplin">Sophie Pouplin</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300147" status="VALID"> <idno type="IdRef">169975681</idno> <orgName>CHU Rouen</orgName> <desc> <address> <addrLine>1, rue de Germont 76031 Rouen cedex</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.chu-rouen.fr/</ref> </desc> <listRelation> <relation active="#struct-455934" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-455934" type="direct"><org type="regroupinstitution" xml:id="struct-455934" status="VALID"> <idno type="IdRef">190906332</idno> <idno type="ISNI">0000000417859671 </idno> <orgName>Normandie Université</orgName> <orgName type="acronym">NU</orgName> <date type="start">2015-01-01</date> <desc> <address> <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.normandie-univ.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Richez, Christophe" sort="Richez, Christophe" uniqKey="Richez C" first="Christophe" last="Richez">Christophe Richez</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300122" status="VALID"> <orgName>CHU Bordeaux [Bordeaux]</orgName> <desc> <address> <addrLine>place Amélie Raba Léon33076 BORDEAUX CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-bordeaux.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-439755" status="VALID"> <orgName>Hôpital de la Cavale Blanche - CHRU Brest</orgName> <orgName type="acronym">CHU - BREST </orgName> <desc> <address> <addrLine>Boulevard Tanguy Prigent 29609 Brest Cedex</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Mezieres, Maryse" sort="Mezieres, Maryse" uniqKey="Mezieres M" first="Maryse" last="Mezieres">Maryse Mezieres</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-18258" status="VALID"> <orgName>Service de rhumatologie [CHU Cochin]</orgName> <desc> <address> <addrLine>27 rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Gutermann, Loriane" sort="Gutermann, Loriane" uniqKey="Gutermann L" first="Loriane" last="Gutermann">Loriane Gutermann</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Gaudin, Philippe" sort="Gaudin, Philippe" uniqKey="Gaudin P" first="Philippe" last="Gaudin">Philippe Gaudin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-58056" status="VALID"> <orgName>Groupe de Recherche et d'Etudes du Processus Inflammatoire</orgName> <orgName type="acronym">GREPI</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation name="EA2938" active="#struct-51016" type="direct"></relation> </listRelation> <tutelles><tutelle name="EA2938" active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD"> <idno type="IdRef">026404796</idno> <orgName>Université Joseph Fourier - Grenoble 1</orgName> <orgName type="acronym">UJF</orgName> <date type="end">2015-12-31</date> <desc> <address> <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ujf-grenoble.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author><author><name sortKey="Wendling, Daniel" sort="Wendling, Daniel" uniqKey="Wendling D" first="Daniel" last="Wendling">Daniel Wendling</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-53272" status="VALID"> <orgName>Service de Rhumatologie</orgName> <desc> <address> <addrLine>Besançon</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300165" type="direct"></relation> <relation active="#struct-301131" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300165" type="direct"><org type="institution" xml:id="struct-300165" status="VALID"> <orgName>Centre Hospitalier Régional Universitaire [Besançon]</orgName> <orgName type="acronym">CHRU Besançon</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.chu-besancon.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-301131" type="direct"><org type="institution" xml:id="struct-301131" status="VALID"> <orgName>Hôpital Jean Minjoz</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-18258" status="VALID"> <orgName>Service de rhumatologie [CHU Cochin]</orgName> <desc> <address> <addrLine>27 rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1016/j.jbspin.2018.08.006</idno><series><title level="j">Joint Bone Spine</title><idno type="ISSN">1297-319X</idno><imprint><date type="datePub">2019-01</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Adherence</term><term>Compliance</term><term>Recommendations</term><term>Rheumatoid arthritis</term><term>Spondyloarthritis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>BACKGROUND:Adherence to treatment is a key issue in chronic inflammatory rheumatic diseases (CIRDs).OBJECTIVE:To develop recommendations to facilitate in daily practice, the management of non-adherence to disease-modifying drugs in patients with rheumatoid arthritis, spondyloarthritis, psoriatic arthritis, connective tissue diseases or other CIRDs.METHODS:The process comprised (a) systematic literature reviews of methods (including questionnaires) to measure non-adherence, risk factors for non-adherence and efficacy of targeted interventions; (b) development of recommendations through consensus of 104 rheumatologist and nurse experts; (c) assessment of agreement and ease of applicability (1-5 where 5 is highest) by the 104 experts.RESULTS:(a) Overall, 274 publications were analysed. (b) The consensus process led to 5 overarching principles and 10 recommendations regarding adherence. Key points include that adherence should be assessed at each outpatient visit, at least using an open question; questionnaires and hydroxychloroquine blood level assessments may also be useful. Risk factors associated to non-adherence were listed. Patient information and education, and patient/physician shared decision, are key to optimize adherence. Other techniques such as formalized education sessions, motivational interviewing and cognitive behavioral therapy may be useful. All health professionals can get involved and e-health may be a support. (c) The agreement with the recommendations was high (range of means, 3.9-4.5) but ease of applicability was lower (2.7-4.4).CONCLUSIONS:Using an evidence-based approach followed by expert consensus, this initiative should improve the assessment and optimization of adherence in chronic inflammatory rheumatic disorders.</p> </div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement><orgName><li>Université Grenoble-Alpes</li><li>Université Joseph Fourier</li><li>Université de Grenoble</li></orgName></list><tree><noCountry><name sortKey="Senbel, Eric" sort="Senbel, Eric" uniqKey="Senbel E" first="Eric" last="Senbel">Eric Senbel</name></noCountry><country name="France"><noRegion><name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name></noRegion><name sortKey="Beauvais, Catherine" sort="Beauvais, Catherine" uniqKey="Beauvais C" first="Catherine" last="Beauvais">Catherine Beauvais</name><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name><name sortKey="Flipo, Rene Marc" sort="Flipo, Rene Marc" uniqKey="Flipo R" first="René-Marc" last="Flipo">René-Marc Flipo</name><name sortKey="Gaudin, Philippe" sort="Gaudin, Philippe" uniqKey="Gaudin P" first="Philippe" last="Gaudin">Philippe Gaudin</name><name sortKey="Gutermann, Loriane" sort="Gutermann, Loriane" uniqKey="Gutermann L" first="Loriane" last="Gutermann">Loriane Gutermann</name><name sortKey="Lavielle, Matthieu" sort="Lavielle, Matthieu" uniqKey="Lavielle M" first="Matthieu" last="Lavielle">Matthieu Lavielle</name><name sortKey="Mezieres, Maryse" sort="Mezieres, Maryse" uniqKey="Mezieres M" first="Maryse" last="Mezieres">Maryse Mezieres</name><name sortKey="Molt, Anna" sort="Molt, Anna" uniqKey="Molt A" first="Anna" last="Molt">Anna Molt</name><name sortKey="Pouplin, Sophie" sort="Pouplin, Sophie" uniqKey="Pouplin S" first="Sophie" last="Pouplin">Sophie Pouplin</name><name sortKey="Puyraimond Zemmour, Deborah" sort="Puyraimond Zemmour, Deborah" uniqKey="Puyraimond Zemmour D" first="Déborah" last="Puyraimond-Zemmour">Déborah Puyraimond-Zemmour</name><name sortKey="Richez, Christophe" sort="Richez, Christophe" uniqKey="Richez C" first="Christophe" last="Richez">Christophe Richez</name><name sortKey="Romand, Xavier" sort="Romand, Xavier" uniqKey="Romand X" first="Xavier" last="Romand">Xavier Romand</name><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><name sortKey="Wendling, Daniel" sort="Wendling, Daniel" uniqKey="Wendling D" first="Daniel" last="Wendling">Daniel Wendling</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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